Research Projects

Proteins

Aβ - Structural Details of the Tetramer

We evaluate models of Aβ tetramers in atomic detail. Models considered include annealed structures of four randomly assembled monomers and four molecules arranged in a cross-β orientation similar to that found in fibrils.

See also:

• Our presentation: Significance of the tetramer structure (pp. 70-72) from a talk entitled Ion mobility: The method & recent applications given at the 55th ASMS Conference on Mass Spectrometry in June, 2007
• Related work: "Molecular dynamics simulations of Alzheimer’s β-amyloid protofilaments" by N.-V. Buchete, R. Tycko, G. Hummer [5]