In this area of research, we use ion mobility mass spectrometry combined with molecular modeling to determine three-dimensional structure and investigate reaction mechanisms and energetics for systems important in materials chemistry. Much of the materials research conducted in the Bowers group is done in conjunction with research groups specializing in synthesis. Of course, the goal of these research groups is to characterize their newly developed products, but this is sometimes not possible with traditional methods, such as NMR and x-ray crystallography. This is especially true when important structural features are subtle. In such cases, ion mobility methods can often provide an answer. With our techniques, not only are we able to study these systems from a physical-chemistry point of view, we are also able to provide important structural feedback to synthesis groups for rational design of new materials.