Biosynthetic considerations of triscatechol siderophores framed on serine and threonine macrolactone scaffolds.

TitleBiosynthetic considerations of triscatechol siderophores framed on serine and threonine macrolactone scaffolds.
Publication TypeJournal Article
Year of Publication2017
AuthorsReitz ZL, Sandy M, Butler A
JournalMetallomics
Volume9
Issue7
Pagination824-839
Date Published2017 Jul 19
ISSN1756-591X
Abstract

Bacteria often produce siderophores to facilitate iron uptake. One of the most studied siderophores is enterobactin, the macrolactone trimer of 2,3-dihydroxybenzoyl-l-serine, produced by E. coli and many other enteric bacteria. Other siderophores are variants of enterobactin, with structural modifications including expansion of the tri-serine core to a tetra-serine macrolactone, substitution of l-serine with l-threonine, insertion of amino acids (i.e., Gly, l-Ala, d-Lys, d- and l-Arg, l-Orn), catechol glucosylation, and linearization of the tri-serine macrolactone core. In this review we summarize the current understanding of the biosyntheses of these enterobactin variants, placing them in contrast with the well-established biosynthesis of enterobactin.

DOI10.1039/c7mt00111h
Alternate JournalMetallomics
PubMed ID28594012