Title | Biosynthetic considerations of triscatechol siderophores framed on serine and threonine macrolactone scaffolds. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Reitz ZL, Sandy M, Butler A |
Journal | Metallomics |
Volume | 9 |
Issue | 7 |
Pagination | 824-839 |
Date Published | 2017 Jul 19 |
ISSN | 1756-591X |
Abstract | Bacteria often produce siderophores to facilitate iron uptake. One of the most studied siderophores is enterobactin, the macrolactone trimer of 2,3-dihydroxybenzoyl-l-serine, produced by E. coli and many other enteric bacteria. Other siderophores are variants of enterobactin, with structural modifications including expansion of the tri-serine core to a tetra-serine macrolactone, substitution of l-serine with l-threonine, insertion of amino acids (i.e., Gly, l-Ala, d-Lys, d- and l-Arg, l-Orn), catechol glucosylation, and linearization of the tri-serine macrolactone core. In this review we summarize the current understanding of the biosyntheses of these enterobactin variants, placing them in contrast with the well-established biosynthesis of enterobactin. |
DOI | 10.1039/c7mt00111h |
Alternate Journal | Metallomics |
PubMed ID | 28594012 |