Mechanistic considerations of halogenating enzymes.

TitleMechanistic considerations of halogenating enzymes.
Publication TypeJournal Article
Year of Publication2009
AuthorsButler A, Sandy M
JournalNature
Volume460
Issue7257
Pagination848-54
Date Published2009 Aug 13
ISSN1476-4687
KeywordsBiocatalysis, Enzymes, Halogenation, Halogens, Peroxidases
Abstract

In nature, halogenation is a strategy used to increase the biological activity of secondary metabolites, compounds that are often effective as drugs. However, halides are not particularly reactive unless they are activated, typically by oxidation. The pace of discovery of new enzymes for halogenation is increasing, revealing new metalloenzymes, flavoenzymes, S-adenosyl-L-methionine (SAM)-dependent enzymes and others that catalyse halide oxidation using dioxygen, hydrogen peroxide and hydroperoxides, or that promote nucleophilic halide addition reactions.

DOI10.1038/nature08303
Alternate JournalNature
PubMed ID19675645
Grant ListR01 GM038130 / GM / NIGMS NIH HHS / United States
R01 GM038130-15 / GM / NIGMS NIH HHS / United States
R01 GM038130-16 / GM / NIGMS NIH HHS / United States