Title | Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Sandy M, Han A, Blunt J, Munro M, Haygood M, Butler A |
Journal | J Nat Prod |
Volume | 73 |
Issue | 6 |
Pagination | 1038-43 |
Date Published | 2010 Jun 25 |
ISSN | 1520-6025 |
Keywords | Animals, Antineoplastic Agents, Arginine, Drug Screening Assays, Antitumor, Leukemia P388, Marine Biology, Mice, Molecular Structure, Peptides, Serine, Siderophores, Vibrio |
Abstract | The marine bacterium Vibrio sp. DS40M4 has been found to produce a new triscatechol amide siderophore, trivanchrobactin (1), a related new biscatecholamide compound, divanchrobactin (2), and the previously reported siderophores vanchrobactin (3) and anguibactin (4). Vanchrobactin is comprised of l-serine, d-arginine, and 2,3-dihydroxybenzoic acid, while trivanchrobactin is a linear trimer of vanchrobactin joined by two serine ester linkages. The cyclic trivanchrobactin product was not detected. In addition to siderophore production, extracts of Vibrio sp. DS40M4 were screened for biologically active molecules; anguibactin was found to be cytotoxic against the P388 murine leukemia cell line (IC(50) < 15 microM). |
DOI | 10.1021/np900750g |
Alternate Journal | J. Nat. Prod. |
PubMed ID | 20521785 |
PubMed Central ID | PMC3065854 |
Grant List | GM38130 / GM / NIGMS NIH HHS / United States R01 GM038130-16 / GM / NIGMS NIH HHS / United States |