Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4.

TitleVanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4.
Publication TypeJournal Article
Year of Publication2010
AuthorsSandy M, Han A, Blunt J, Munro M, Haygood M, Butler A
JournalJ Nat Prod
Date Published2010 Jun 25
KeywordsAnimals, Antineoplastic Agents, Arginine, Drug Screening Assays, Antitumor, Leukemia P388, Marine Biology, Mice, Molecular Structure, Peptides, Serine, Siderophores, Vibrio

The marine bacterium Vibrio sp. DS40M4 has been found to produce a new triscatechol amide siderophore, trivanchrobactin (1), a related new biscatecholamide compound, divanchrobactin (2), and the previously reported siderophores vanchrobactin (3) and anguibactin (4). Vanchrobactin is comprised of l-serine, d-arginine, and 2,3-dihydroxybenzoic acid, while trivanchrobactin is a linear trimer of vanchrobactin joined by two serine ester linkages. The cyclic trivanchrobactin product was not detected. In addition to siderophore production, extracts of Vibrio sp. DS40M4 were screened for biologically active molecules; anguibactin was found to be cytotoxic against the P388 murine leukemia cell line (IC(50) < 15 microM).

Alternate JournalJ. Nat. Prod.
PubMed ID20521785
PubMed Central IDPMC3065854
Grant ListGM38130 / GM / NIGMS NIH HHS / United States
R01 GM038130-16 / GM / NIGMS NIH HHS / United States