Vanadium bromoperoxidase from Delisea pulchra: enzyme-catalyzed formation of bromofuranone and attendant disruption of quorum sensing.

TitleVanadium bromoperoxidase from Delisea pulchra: enzyme-catalyzed formation of bromofuranone and attendant disruption of quorum sensing.
Publication TypeJournal Article
Year of Publication2011
AuthorsSandy M, Carter-Franklin JN, Martin JD, Butler A
JournalChem Commun (Camb)
Volume47
Issue44
Pagination12086-8
Date Published2011 Nov 28
ISSN1364-548X
KeywordsAgrobacterium tumefaciens, beta-Galactosidase, Furans, Peroxidases, Quorum Sensing, Rhodophyta
Abstract

Vanadium bromoperoxidase was isolated and cloned from the marine red alga Delisea pulchra. This enzyme catalyzes the bromolactonization of 4-pentynoic acid forming 5E-bromo-methylidenetetrahydro-2-furanone, a compound which is shown herein to inhibit quorum sensing in the engineered reporter strain, Agrobacterium tumefaciens NTL4.
DOI10.1039/c1cc15605e
Alternate JournalChem. Commun. (Camb.)
PubMed ID22006105