Principal Investigator

My research interests are in bioinorganic chemistry and metallobiochemistry with an emphasis on elucidating roles of metal ions in catalysis by metalloenzymes, as well as processes by which microbes acquire metal ions they need to grow. We are currently focusing on the biosynthesis of siderophores in regards to microbial iron acquisition, with a focus on chirality in biosynthesis and chirality of the Fe(III)-siderophores; the role of haloperoxidases in disruption of microbial quorum sensing, as well as in cryptic halogenation reactions; the design of catechol compounds for wet adhesion; and the role of microbial peroxidases in lignin disassembly.

Graduate Students

My work explores the form-function relationship of iterative non-ribosomal peptide synthetases (NRPSs) involved in siderophore biosynthesis through cloning and site-directed mutagenesis. I am also isolating and characterizing bacterial siderophores predicted through genome mining techniques.