Bioactive
Peptides
The
following biologically relevant peptides were studied (structure and/or
hydration):
- Bradykinin
(plasma polypeptide)
- LHRH
(hypothalamic hormone) [2]
- Neurotensin
(gastrointestinal hormone)
- Oxytocin
(pituitary hormone) [3]
- Amyloid
β-peptide (extracellular protein involved in Alzheimer's
disease) [4]
- structure
and early stages of aggregation
References and comments:
- "Gas-phase conformation of biological molecules: Bradykinin"
T. Wyttenbach, G. von Helden, M. T. Bowers J.
Am. Chem. Soc. 1996, 118, 8355-8364
- Hydration of bradykinin and LHRH was studied by experiment and molecular
modeling. Results are briefly discussed in the context of zwitterions
on our zwitterion web
page. Experimental hydration results on bradykinin, LHRH, and neurotensin
and some aspects of the modeling results on bradykinin and LHRH are
covered in the following two publications.
- "Oxytocin-receptor binding: Why divalent metals are essential"
D. Liu, A. B. Seuthe, O. T. Ehrler, X. Zhang, T. Wyttenbach, J. F. Hsu,
M. T. Bowers J.
Am. Chem. Soc. 2005, 127, 2024-2025
- "Amyloid β-protein: Monomer structure and early
aggregation states of Aβ42 and its Pro19 alloform"
S. L. Bernstein, T. Wyttenbach, A. Baumketner, J.-E. Shea, G. Bitan,
D. B. Teplow, M. T. Bowers J.
Am. Chem. Soc. 2005, 127, 2075-2084
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