Methoxatin, PQQ and Related ortho-quinones

264. T.S. Eckert; T.C. Bruice; J.A. Gainor and S.M. Weinreb. Some electrochemical and chemical properties of methoxatin and analogous quinoquinones. Proc. Natl. Acad. Sci. (USA) 1982, 79, 2533.

270. D. Igdaloff; D.V. Santi; T.S. Eckert and T.C. Bruice. Effects of 1,7- and 1,10-phenanthroline dione on tissue culture cells. Biochem. Pharmacol. 1983, 32, 172.

276. T.S. Eckert and T.C. Bruice. Chemical Properties of Phenanthrolinequinones and the Mechanism of Amine Oxidation by O-Quinones of Medium Redox Potentials. J. Am. Chem. Soc. 1983, 105, 4431.

303. P.R. Sleath; J.B. Noar; G.A. Eberlein; and T.C. Bruice. Synthesis of 7,9-Didecarboxymethoxatin (4,5-Dihydro-4,5-dioxo-1H- [pyrrolo[2,3-f]quinoline-2-carboxylic Acid) and Comparison of Its Chemical Properties with Those of Methoxatin and Analogous O-Quinones. Model Studies Directed Towards the Action of PQQ Requiring Bacterial Oxoreductases and Mammalian Plasma Amine Oxidase. J. Am. Chem. Soc. 1985, 107, 3328.

308. M. Conlin; H.S. Forrest and T.C. Bruice. Replacement of Methoxatin by 4,7-Phenanthroline-5,6-dione and the Inability of Other Phenanthroline Quinones, As Well As 7,9-Di-decarboxy Methoxatin, to Serve as Cofactors for the Methoxatin-Requiring Glucose Dehydrogenase of AcinotobacterCalcoaceticus. Biochem. and Biophys. Res. Commun. 1985, 131, 564.

309. J.B. Noar; E.J. Rodriguez and T.C. Bruice. Synthesis of 9-Decarboxymethoxatin. Metal Complexation of Methoxatin as a Possible Requirement for Its Biological Activity. J. Am. Chem. Soc. 1985, 107, 7198.

329. E.J. Rodriguez; T.C. Bruice and D.E. Edmondson. Studies on the Radical Species of 9-Decarboxymethoxatin. J. Am. Chem. Soc. 1987, 109, 532.

334. J.B. Noar and T.C. Bruice. Decarboxylated Methoxatin Analogues. Synthesis of 7- and 9-Decarboxymethoxatin. J. Org. Chem. 1987, 52, 1942.

360. E.J. Rodriguez and T.C. Bruice. Reaction of Methoxatin and 9- Decarboxymethoxatin with Benzylamine. Dynamics and Products. J. Am. Chem. Soc. 1989, 111, 7947.

459. Y-J. Zheng & T. C. Bruice. Conformation of coenzyme Pyrroloquinolinequinone (PQQ) and the Role of Ca2+ in the Catalytic Mechanism of Quinoprotein Methanol Dehydrogenase. Proc. Natl. Acad. Sci. (USA) 1997, 94, 11881.

505. Zheng, Y.-J.; Xia, Z.-X.; Chen, Z.-W.; Mathews, F. S.; Bruice, T. C.. Catalytic mechanism of quinoprotein methanol dehydrogenase: a theoretical and x-ray crystallographic investigation. Proc. Natl. Acad. Sci. (USA) 2001, 98, 432-434.

534. Reddy, S. Y., Mathews, F. S., Zheng, Y-J. and Bruice, T. C.. PQQ Methanol dehydrogenase: A Molecular dynamic study and comparison with crystal structure. J. Mol. Struct. 2003, 655 (2), 269-277. PDF

538. Reddy, S. Y. and Bruice, T. C.. In silico studies of the mechanism of methanol oxidation by quinoprotein methanol dehydrogenase. J. Am. Chem. Soc. 2003, 125, 8141-8150. PDF and Supporting Info

547. Reddy, S. Y. & Bruice, T. C., Mechanism of glucose oxidation by quinoprotein soluble glucose dehydrogenase: Insights from molecular dynamics studies. J. Am. Chem. Soc., 2004, 126, 2431-2438. PDF, Supporting Information

553. Reddy, S.Y. & Bruice, T.C., Review: Determination of enzyme mechanisms by molecular dynamic studies on quinoproteins, methanol dehydrogenase and soluble glucose dehydrogenase, Protein Science, 2004, 13, 1965-1978. PDF

554. Reddy, S.Y. & Bruice, T.C., Mechanisms of ammonia activation and ammonium ion inhibition of quinoprotein methanol dehydrogenase: A computational approach. Proc. Natl. Acad. Sci. (USA), 2004, 101(45), 15887-15892. PDF