Synthesis of Hindered α-Amino Carbonyls: Copper-Catalyzed Radical Addition with Nitroso Compounds.

TitleSynthesis of Hindered α-Amino Carbonyls: Copper-Catalyzed Radical Addition with Nitroso Compounds.
Publication TypeJournal Article
Year of Publication2015
AuthorsFisher DJ, G Burnett L, Velasco R, Read de Alaniz J
JournalJ. Am. Chem. Soc
Volume137
Start Page11614
Pagination11614-7
ISSN1520-5126
Abstract

The synthesis of sterically hindered anilines has been a significant challenge in organic chemistry. Here we report a Cu-catalyzed radical addition with in situ-generated nitroso compounds to prepare sterically hindered amines directly from readily available materials. The transformation is conducted at room temperature, uses abundant copper salts, and is tolerant of a range of functional groups.

DOI10.1021/jacs.5b07860
PubMed ID26317926