2025

Hernandez, I.; Jin, K. C.; Yang, Y.; Konttinen, O.; Lantz, A.; Zhao, Y.; Squire, I.; Pettus, T. R. R.;  Reich, N. O. “Allosteric Inhibitors of Cell-Cycle-Regulated Methyltransferase for Novel Antibiotic Development”  ACS Omega, 2025, 10, 15775-15780. 78.pdf

2024

Hernandez, I.; Ward, E.;  Pettus, T. R. R.;  Reich, N. O. “Structural Investigations of Phthalazinone Derivatives as Allosteric Inhibitors of Human DNA Methyltransferase 3A”  ACS Med. Chem. Let, 2024, 15, 590-594 . 77.pdf

2023

Wong, Y. F.; Pettus, T. R. R.“Nucleophilic Imine and Electrophilic o-Quinone Methides, a Tree-Component Assembly of Assorted 3,4-Dihydro-2-H-1,3-benzoxazines”  Synlett. 2023, 21, 7746-7749. 76.pdf

Wong, Y. F.; Hernandez, I.; Pettus, T. R. R.“Nucleophilic Addition of 4,5-Dihydrooxazoles Derivatives to Base Generated o-Quinone Methides: A Four Component Reaction”  J. Org. Chem. 2023, 88, 2583-2588. 75.pdf

2022

Chen, P.; Pettus, T. R. R.“Strategies for ortho-tert-Butylation of Phenols and their Analogs”  Synlett 2022, 33. 575-580. 75.pdf

Bai, W-J.; Jackson, S. K.; Pettus, T. R. R.“Tetrapetalone ruminations, trials and tribulations”  Strategies and Tactics in Organic Synthesis, v15, Ch6, ed. Harmata, M. 2022, 211-246. 74.pdf

2019

Chen, P.; Wong, Y. F.; Pettus, T. R. R.“Nucleophilic Imine and Electrophilic o-Quinone Methides, a Tree-Component Assembly of Assorted 3,4-Dihydro-2-H-1,3-benzoxazines”  Org. Lett. 2019, 21, 7746-7749. 73.pdf

2018

Feng, Z-G.; Burnett, G. L.; Pettus, T. R. R.“A Biomimetic Synthesis of des-Hydroxy Paecilospirone”  Synlett, 2018, 29, 1517-1519. 72.pdf

Bai, W. J.; Pettus, T. R. R.“Synthetic Studies toward the Tetrapetalones: Diastereoselective Construction of a Putative Intermediate”  Org. Lett. 2018, 20, 901-904. 71.pdf

2015

Feng, Z-G.; Bai, W. J.; Pettus, T. R. R.“Unified Total Syntheses of Medicarpin, Sophoracarpan A, and Kushecarpin A with Some Structural Revisions*”  Angew. Chemie., 2015, 54, 1864-1867. 70.pdf

2014

Bai, W. J.; David, J. G.; Feng, Z-G.; Weaver, M. G.; Wu, K-L.; Pettus, T. R. R.“The Domestication of ortho-Quinone Methides”  Acc. Chem. Res., 2014, 47, 3655–3664. 69.pdf

David, J. D.;  Bai, W. J.; Weaver, M. G..; Pettus, T. R. R..“A General Diastereoselective Catalytic Vinylogous Aldol Reaction among Tetramic Acid-Derived Pyrroles”  Org. Lett, 2014. 16, 4384-4387. PMID: 25119431 68.pdf

Weaver, M.G.;  Bai, W. J.; Jackson, S.; Pettus, T. R. R..“Diels–Alder Construction of Regiodifferentiated meta-Amino Phenols and Derivatives”  Org. Lett, 2014. 16, 1294-1297. PMID: 24524325 67.pdf

Weaver, M.G.; Pettus, T. R. R. “Synthesis of para- and ortho-Quinones”  Comprehensive Organic Synthesis, 2nd ed Vol 7, Oxford: Elsevier; 2014. pp. 373-410. 66.pdf

2012

Bai, W. J.; Jackson, S.; Pettus, T. R. R..“Mild Construction of 3-Methyl Tetramic Acids Enabling a Formal Synthesis of Palau’imide”  Org. Lett, 2012, 14, 3862-3865. PMID: 22804621 65.pdf

Green, J. C.; Brown, E.; Pettus, T. R. R. ”Intramolecular Condensation via an ortho-Quinone Methide: Total Synthesis of (±)-Heliol”  Org. Lett. 2012. 14, 2929 - 2931. PMID: 22650973. 64.pdf

Green, J. C.; Burnett, L.; Pettus, T. R. R..“Synthesis and Applications of Chroman Spiroketals”  Pure Appl. Chem. 2012. 84, 1621-1631. 63.pdf

Cohn, E. P. M. T.; Wu, K-L.; Pettus, T. R. R. Reich, N. O. “A New Strategy for the Detection and Development of Tractable Telomerase Inhibitors”  J. Med. Chem. 2012, 55, pp 3678–3686. PMID: 22413845. 62.pdf

Bai, W. J.; Green, J. C.; Pettus, T. R. R..“Total Syntheses of ent-Heliespirones A & C”  J. Org. Chem. 2012, 77, 379-387. PMID: 22074003. 61.pdf

2011

Green, J. C.; Alonso, S. J; Brown, E. R.; Pettus, T. R. R..“Total Synthesis and Repudiation of the Helianane Family” Org. Lett. 2011, 13, 5500–5503. PMID: 21928811. 60.pdf

Wu, K-L.; Mercado, E. V.; Pettus, T. R. R. “A Convergent Total Synthesis of (±)-γ-Rubromycin”  J. Am. Chem. Soc.  2011, 133, 6114–6117. PMID: 21452818. 59.pdf

Jackson, S. K.; Wu, K-L; Pettus, T. R. R. Chapter 19 “Sequential Reactions Initiated by Oxidative Dearomatization. Biomimetic or Artifact?”  in Biomimetic Organic Synthesis . 58.pdf

Cha, J. Y.; Burnett, L.; Davidson, J. B.; Pettus, T. R. R. “A Strategy for Late-Stage Divergent Syntheses of Scyphostatin Analogs”  J. Org. Chem. 2011, 76, 1361–1371. PMID: 21250721. 57.pdf

Green, J.; Pettus, T. R. R. “An Oxidative Dearomatization Induced [5 + 2] Cascade Enabling the Efficient Syntheses of α-Cedrene, α-Pipitzol, and sec-Cedrenol”  J. Am. Chem. Soc.  2011, 133, 1603–1608. PMID: 21194216. 56.pdf

Wenderski, T. A.; Marsini, M. A.; Pettus, T. R. R. “A Diastereoselective Formal Synthesis of Berkelic Acid”  Org. Lett. 2011, 13, 118-121. PMID: 21138313. 55.pdf

2010

Wenderski, T. A.; Hoarau, C; Mejorado, L.; Pettus, T. R. R. “Dearomatization Applications of I(III) Reagents and Unusual Reactivity Amongst Resorcinol Derived Cyclohexadienones”  Tetrahedron, 2010, 66, 5873-5883. PMID: 23750053. 54.pdf

2009

Cha, J. Y.; Huang, Y.; Pettus, T. R. R. “Total Synthesis of TK-57-164A, Isariotin F, and their Putative Progenitor Isariotin E”  Angew. Chemie., Int. ed. 2009, 48, 9519-9521. PMID: 19921667 51. pdf

Wenderski, T. A.; DeNatale, V.; Pettus, T. R. R. “Synthesis of 2,2-disubstituted Pentalenes and Indenes by a Useful Modification to Nakamura’s DMCP [3 + 2] Cycloaddition Protocol ”  Synlett, 2009, 2637-2641. PMID: 21442051. 50. pdf

Miller, L. A..; Marsini, M. A.; Pettus, T. R. R. “Chemoselective Reactions of 3-Benzyloxy-1,2-o-Quinone with Organometallic Reagents” Org. Lett. 2009, 11, 1955–1958. PMID: 19331343. 49.pdf

Wenderski, T. A.; Huang, S.; Pettus, T. R. R. “Enantioselective Total Synthesis of All of the Known Chiral Cleroindicins (C-F): Clarification Among Some Assignments and Optical Rotations”  J. Org. Chem. 2009, 74, 4104-9. PMID: 19476394. 48.pdf

Wu, K.-L.; Cohn, P. M. T.; Huang, Y.; Pettus, T. R. R. “ First Total Synthesis of Malvone A and Formal Syntheses of Boryquinone and Hybocarpone Using a Concise Strategy for Construction of Unsymmetrical Naphthoquinones”  Synlett, 2009, 1273-1276.  47.pdf

Pettus, L. H.; Pettus, T. R. R. “Intermolecular Applications of o- Quinone Methides (o-QMs) Anionically Generated at Low Temperatures; Kinetic Conditions”  vol 1. o-Quinone Methides: Chapter 4, 89-118, 2009.  46.pdf

2008

Huang, Y-D.; Pettus, T. R. R. “A Cycloaddition Strategy For Use Toward Berkelic Acid, a MMP Inhibitor and Potent Anticancer Agent Displaying a Unique Chroman Spiroketal Motif” Synlett, 2008, 1353-1356. PMID: 19183702.  45.pdf

Marsini, M. A.; Huang, Y.; Lindsey, C.; Wu, K. L.; Pettus, T. R. R. “Diastereoselective Syntheses of Chroman Spiroketals via Cycloaddition of Chiral Enol Ethers and o-Quinone Methides”  Org. Lett. 2008, 10,  1477-1480. PMID: 18336038.  44.pdf

2007

Wu, K.-L.; Wilkinson, S.; Reich, N. O.; Pettus, T. R. R. “Facile Synthesis of Naphthoquinone Spiroketals by Diastereoselective Oxidative [3 + 2] Cycloaddition”  Org. Lett. 2007, 9 (26): 5537-5540. PMID: 18044909.  43.pdf

Marsini, M. A.; Huang, Y.; Van De Water, R. W.; Pettus, T. R. R. “Synthesis of Resorcinol derived Spironitronates” Org. Lett., 2007, 9 (26): 3229-3232. PMID: 17645344.  42.pdf

Wenderski, T.; Pettus, T. R. R. “Seduced by a Siren’s Call:  Expanding Applications for Aromatic Compounds: the Synthesis of (+)-Rishirilide B”  Strategies and Tactics in Organic Synthesis: 2007.  41.pdf

Marsini, M. A.; Pettus, T. R. R. “31.5.2: Arene-OH and Arene-OM”  Science of Synthesis (31): 2007.  40.pdf

2006

Mejorado, L.; Pettus, T. R. R. “The Total Synthesis of (+)-Rishirilide B Enabled by the Enantioselective Oxidative Dearomatization of Resorcinol Derivatives”  J. Am. Chem. Soc. 2006, 128, (49) 15625-15631. PMID: 17147370.  39.pdf

Mejorado, L.; Pettus, T. R. R. “Diastereoselective Synthesis of a Simplified Core Structure of Rishirilide B”  Synlett, 2006, (19), 3209-3214. PMID: 18846264.  38.pdf

Marsini, M. A.; Gowin, K.; Pettus, T. R. R. “The Total Synthesis of (±)-Mitorubrinic Acid”  Org. Lett. 2006, 8, 3481-3483. PMID: 16869640.  37.pdf

Selenski, C.; Pettus, T. R. R. “28.12: Quinomethanes” Science of Synthesis (28): 2006.  36.pdf

Hoarau, C.; Pettus, T. R. R. “A General Synthesis for Chiral 4-alkyl-4-hydroxycyclohexenones” Org. Lett. 2006, 8, 2843-2846. PMID: 16774271.  35.pdf

Lindsey, C. C.; Wu, K. L.; Pettus, T. R. R. “Synthesis of Electron Deficient 5,6-Aryloxy Spiroketals” Org. Lett. 2006, 8 (11): 2365-2367. PMID: 16706527. 34.pdf

Selenski, C.; Pettus, T. R. R. “(±)-Diinsininone: made natures way”  Tetrahedron, 2006, 62 (22): 5298-5307. PMID: 19079766. 33.pdf

Lindsey, C. C.; Pettus, T. R. R. “Unusual cycloadditions of o-quinone methides with oxazoles” Tetrahedron Lett. 2006, 47, 201-204. PMID: 18592015.  32.pdf

2005

Huang, Y.; Zhang, J,; Pettus, T. R. R. “Synthesis of (+/-)-Brazilin using IBX ” Org. Lett. 2005, 7, 5841-5844. PMID: 16354080. 31.pdf

Selenski, C.; Pettus, T. R. R. “Enantioselective Diels-Alder Reactions of o-Quinone Methides:  Total Synthesis of (+)-Mimosifoliol and a Formal Synthesis of (+)-Tolterodine” (Addition/Correction) J. Org. Chem. 2005, 70, 3342-3342. PMID: 15609955. 30.pdf

2004

Selenski, C.; Pettus, T. R. R. “Enantioselective [4+2] cycloadditions of o-quinone methides: total synthesis of (+)-mimosifoliol and formal synthesis of (+)-tolterodine.” J. Org. Chem. 69 (26): 9196-9203, Dec. 24, 2004.  29.pdf

McQuaid, K. M.; Pettus, T. R. R. “Chemoselective epoxidation of electron deficient enones with iodosylbenzene.”  Synlett, 2004, 13, 2403-2405. PMID: 19079634. 28.pdf

Wang, J. H.; Pettus, T. R. R. “A short diastereoselective synthesis of the (±)-rishirilide B core structure.” Tetrahedron Lett. 45 (30): 5895-5899, July 19, 2004. 27.pdf

Selenski, C.; Mejorado, L. H.; Pettus, T. R. R. “Diastereoselective [4+2] reactions of o-quinone methides with a chiral enol ether: Asymmetric synthesis of (+)-R-mimosifoliol.” Synlett (6): 1101-1103, May 6, 2004. 26.pdf

Mejorado, L. H.; Hoarau, C.; Pettus, T. R. R.“Diastereoselective dearomatization of resorcinols directed by a lactic acid tether: Unprecedented enantioselective access to p-quinols.” Org. Lett. 2004, 6, 1535-1538. PMID: 15128229 25.pdf

Magdziak, D.; Meek, S. J.; Pettus, T. R. R. “Cyclohexadienone ketals and quinols: Four building blocks potentially useful for enantioselective synthesis.” Chemical Reviews, 2004, 104,  1383-1429. PMID: 15008626. 24.pdf

Wang J.; Pettus L. H.; Pettus, T. R. R. “Cycloadditions of o-quinone dimethides with p-quinol derivatives: regiocontrolled formation of anthracyclic ring systems.” Tetrahedron Lett. 45 (8): 1793-1796, Feb. 16, 2004. 23.pdf

Lindsey, C. C.; O'Boyle, B. M.; Mercede, S. J.; Pettus, T. R. R.“Construction of previously inaccessible 2-amino-4-benzyl substituted oxazoles.” Tetrahedron Lett. 45 (4): 867-868, Jan. 19, 2004. 22.pdf

2003

Tuttle, K.; Rodriguez, A. A.; Pettus, T. R. R.“An expeditious synthesis of (+/-)-mimosifoliol utilizing a cascade involving an o-quinone methide intermediate.” Synlett (14): 2234-2236, Nov. 2003. 21.pdf

Van de Water, R. W.; Hoarau, C.; Pettus, T. R. R. “Oxidative dearomatization of resorcinol derivatives: useful conditions leading to valuable cyclohexa-2,5-dienones.” Tetrahedron Lett. 44 (27): 5109-5113, June 30, 2003. 20.pdf

Hoarau, C.; Pettus, T. R. R. “Strategies for the preparation of differentially protected ortho-prenylated phenols.” Synlett (1): 127-137, Jan. 2003. 19.pdf

2002

Jones, R. M.; Selenski, C.; Pettus, T. R. R. “Rapid syntheses of benzopyrans from o-OBOC salicylaldehydes and salicyl alcohols: A three-component reaction.” J. Org. Chem. 2002, 67, 6911-6915. PMID: 12353982. 18.pdf

Van de Water, R.W.; Pettus, T. R. R.“o-quinone methides: intermediates underdeveloped and underutilized in organic synthesis” Tetrahedron 58 (27): 5367-5405, July 1, 2002. 16.pdf

Lindsey, C. C.; Gomez-Diaz, C.; Villalba, J. M.; Pettus, T. R. R. “Synthesis of the F11334's from o-prenylated phenols: mu M inhibitors of neutral sphingomyelinase (N-SMase).” Tetrahedron 58 (22): 4559-4565, May 27, 2002. 15.pdf

Magdziak, D.; Rodriguez, A. A.; Van De Water, R. W.; Pettus, T. R. R.“Regioselective oxidation of phenols to o-quinones with o-iodoxybenzoic acid (IBX).” Org. Lett. 2002, 4, 285-288. PMID: 11796071. 14.pdf

2001

Jones, R. M.; Van de Water, R.W.; Lindsey, C. C.; Pettus, T. R. R.“A mild anionic method for generating o-quinone methides: Facile preparations of ortho-functionalized phenols.” J. Org. Chem. 2001, 66, 3435-3441. PMID: 11348127. 13.pdf

Pettus, L. H.; Van de Water, R. W.; Pettus, T. R. R. “Synthesis of (±)-epoxysorbicillinol using a novel cyclohexa-2,5-dienone with synthetic applications to other sorbicillin derivatives.” Org. Lett. 2001, 3, 905-908. PMID: 11263912. 12.pdf

Magdziak, D.; Pettus L. H.; Pettus, T. R. R. “Enantioselective hydride abstraction in organic substrate: A novel use for chiral carbenium ions.” Org. Lett. 2001, 3, 557-55. PMID: 11178824. 11.pdf

2000

Van de Water, R.W.; Magdziak, D. J.; Chau, J. N.; Pettus, T. R. R.“New construction of ortho ring-alkylated phenols via generation and reaction of assorted o-quinone methides.” J. Am. Chem. Soc. 122 (27): 6502-6503, Jul. 12, 2000. 10.pdf

Postdoc, graduate & undergraduate work

Pettus, T. R. R.; Inoue, M.; Chen, X-T.; Danishefsky, S. J. “A fully synthetic route to the neurotrophic illicinones: Syntheses of tricycloillicinone and bicycloillicinone aldehyde” J. Am. Chem. Soc. 122 (26): 6160-6168. July 5, 2000. 9.pdf

Martello, L. A.; McDaid, H. M.; Regl, D. L.; Yang, C. P. H.; Meng, D. F.; Pettus, T. R. R.; Kaufman, M. D.; Arimoto, H.; Danishefsky, S. J.; Smith, A. B.; Horwitz, S. B. “Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines.” Clinical Cancer Research 6 (5): 1978-1987. PMID: 10815923. 8.pdf

Chen, X. T.; Bhattacharya, S. K.; Zhou, B. S.; Gutteridge, C.E.; Pettus, T. R. R. Danishefsky, S. J. “The total synthesis of eleutherobin.” J. Am. Chem. Soc. 121 (28): 6563-6579, July 21, 1999. 7.pdf

Pettus, T. R. R.; Chen, X. T.; Danishefsky, S. J. “A fully synthetic route to the neurotrophic illicinones by sequential aromatic claisen rearrangements.” J. Am. Chem. Soc. 120 (48): 12684-12685, Dec. 9 1998. 6.pdf

Chen, X. T.; Zhou, B. S.; Bhattacharya, S. K.; Gutteridge, C.E.; Pettus, T. R. R.; Danishefsky, S. J. “The total synthesis of eleutherobin: A surprise ending.” Angew. Chem. Int. Ed. 37 (6): 789-792, Apr. 3, 1998. 5.pdf

Chen, X. T.; Gutteridge, C.E.; Bhattacharya, S. K.; Zhou, B. S.; Pettus, T. R. R.; Hascall, T.; Danishefsky, S. J. “A convergent route for the total synthesis of the eleuthesides.” Angew. Chem. Int. Ed. 37 (1-2): 185-187, Feb. 2, 1998. 4.pdf

Pettus, T. R. R.; Schlessinger R. H. “A high yielding procedure for preparation of mono-carboxylate surrogates of allenic dicarboxylates and diesters.” Syn. Comm. 32 (19): 3019-3025, 2002. 17.pdf

Schlessinger, R. H.; Wu, X. H.; Pettus, T. R. R. ”Diastereoselective Diels-Alder Reactions using furans substituted with a proline derived auxiliary.” Synlett (5): 536-538 Sp. Iss. SI May 1995. 3.pdf

Schlessinger, R. H.; Pettus, T. R. R.; Springer, J. P. ”Diastereoselective Diels-Alder Reactions using furans substituted with a nonracemic amine.” J. Org. Chem. 59 (12): 3246-3247, Jun. 17, 1994.  2.pdf

Hudlicky, T,; Seoane, G.; Pettus, T. R. R. “Enantioselective Synthesis of (-)-Zeylena from Styrene.” J. Org. Chem. 54 (17): 4239-4243, Aug. 18, 1989. 1.pdf